Water coming from frog/fish racks; safe for use on all equipment coming in contact with frogs/fish of that system.
A systemic analgesic is a drug that provides pain relief to the entire body.
Amputation of the tail of a lamb.
Water coming out of the sink faucet; contains chlorine, which is bad for the fish and will kill them. If used to wash equipment, make sure equipment is dry before using it or rinse it with system water.
Codes used by lab personnel to indicate the type of care provided.
- F: Feed provided (restricted or topped off)
- W: Water bottle topped off
- CW: Changed water bottle
- CC: Cage change performed
- S: New cage started
Technician Time Charges
- Supplies: An amount or quantity of a commodity that is needed outside the normal per-diem fee schedule. For example: additional cages, water bottles when placed long-term on ventilated racks, and non-standard lab requested Personal Protective Equipment (PPE). Note: the time spent and/or service provided must also be charged to the lab monthly.
- Services: To provide time and assistance with a specific job/ task above and beyond standard husbandry duties. For example: euthanasia, amount of time spent changing diabetic animal cages, etc. Technician time may also refer to additional supplies used and provided beyond the normal standard operating procedures.
- Technical Services: Laboratory requested contracted services to be provided by the ULAM Technical Service Team. For example: checking plugs, tagging, tailing, bleeds, injections, measure tumors, etc. Note: the time it takes to provide the service will be billed in 15-minute increments unless management approves otherwise.
- Overtime: Will be charged to time spent providing additional services on weekends, holidays, or after regular working hours (6:00 AM - 4:15 PM). Overtime charges will be a multiplication of the total time on weekends/holidays/after hours by 1.5 (ULAM Business Office personnel will perform this calculation).
Tecniplast Recirculating Tank System
Standard recirculating housing for frogs and fish in which water recirculates throughout the rack.
Temperature Set Point
Room temperature desired to be maintained for each species according to the room temperature table (see Appendix A in the Animal Room Environmental Monitoring SOP).
Sticker that is placed on equipment processed through cage wash machines that indicates highest temperature equipment reached up to 180°F.
An agent capable of causing developmental abnormalities.
This method of eradication is an option for most viral outbreaks in SPF barrier rodent rooms (i.e. rodents housed in microisolator cages). Because microisolator cages are individual biologic units, if appropriate technique is used, there should be minimal risk of viral spread from cage to cage. Eradication is directed at testing one or all mice in each cage and euthanizing any positive cages. This definition may change in unique circumstances.
The Elements Of Fire
The fire tetrahedron can be applied to fires associated with animal use procedures.
Device capable of reading max/current/min temperature as well as relative humidity.
The application of substances directly to the skin for topical effect.
An antigenic poison or venom of plant or animal origin, especially one produced by or derived from microorganisms and causing disease when present at low concentration in the body.
A vaccine administered for long-term protection against a bacterial toxin.
The application of substances directly to the skin for systemic effect.
Complete cage set up; including cage bottom, feeder, and micro-isolation top.
This indicates this animal is being treated for tumor ulceration or a condition secondary to its tumor burden after veterinary consultation or as outlined in the animal use protocol (ex. diet gel will be provided when body condition drops below a 3 out of 5).
Document any laboratory approved ULAM veterinary treatment recommendations (i.e. dietary supplementation, SQ fluids, topical triple antibiotic ointment, etc) on the Tumor Monitoring Form - Cage Card Size (see Appendix A of the Guidelines and SOP on Tumor Monitoring) or on the Tumor Monitoring Form - Notebook Size (see Appendix B of the Guidelines and SOP on Tumor Monitoring) and include the date of treatment, the unique identifier of the cage treated, the treatment itself, and the initials of the person administering the treatment.
Treatment and Observation Sheet
A full-page form used for documenting information for inclusion in the permanent medical record.
A cage card-sized form for recording rodent treatments as they are completed. This is one option for documenting treatments provided by investigative personnel.
Alternative breeding strategy in which two adult females and one adult male are co-housed and left together following the birth of pups, resulting in a maximum of two litters and three adults in a cage. To engage in trio birthing, justification for overcrowding must be submitted to and approved by the IACUC.
Alternative breeding strategy in which two adult females and one adult male are co-housed . Unless otherwise approved, one of the adult females must be removed prior to parturition such that no more than two adults and one litter are in the cage at any given time. Justification for overcrowding may be submitted to the IACUC and if approved, trio birthing may be used. Singly housed pregnant females or stud males should be labeled with a blue tab as described in the Identifying Single Housed Animals SOP.
Technical Service Team. Part of the Unit for Laboratory Animal Medicine (ULAM). E-mail address: ULAM-Techservice@med.umich.edu.
A sterile liquid containing the growth products of, or specific substances extracted from the tubercule bacillus.
Applied generally to diseases caused by the tuberculous group of bacteria in the genus Mycobacteria.
Tumor Monitoring Exam
A hands-on exam evaluating for each animal for body condition score, hydration, general behavior, mobility and other contributors to the End-Stage Illness Scoring System in addition to any protocol-specific endpoints like tumor size or tumor ulceration.
Tumor Monitoring Records
A record maintained by investigative personnel that includes the dates and observation codes for animals with experimentally induced tumors. Detailed information on tumor monitoring can be found in the Guidelines and SOP on Tumor Monitoring.
U-M Affiliated Instructors/Demonstrators
U-M Affiliated Instructors/Demonstrators are individuals whose primary animal activity is the leading of teaching activities or demonstration of animals or animal procedures.
Unit for Laboratory Animal Medicine. ULAM provides veterinary care to all animals housed on U-M’s campus. ULAM also manages animal ordering and acquisition, animal transport, animal husbandry and housing, personnel training, animal enrichment, and specialized research support services.
ULAM Approved Vendors
These are the larger vendors, which have a long history of robust health monitoring standards and communication of positive test results. The faculty veterinarians have established that animals from these vendors do not need to be quarantined upon arrival and can be sent directly to housing rooms. All purchase requests are handled by the ULAM Ordering Team.
ULAM Conditionally Approved Vendors
These are vendors which the faculty veterinarians have determined to meet the qualifications for providing high health status reasearch animals. However, these vendors require ongoing evaluation to ensure their health monitoring standards remain high, due to an absence of history of health status communication. The Rodent Health Surveillance Team’s (RHST’s) faculty veterinarian and/or import coordinator will review the health reports and program descriptions routinely. As long as they have this status, animals from these vendors do not need to be quarantined upon arrival and can be sent directly to housing rooms. All purchase requests are handled by the ULAM Ordering Team.
ULAM Containment Coordinator
ULAM faculty member with oversight of issues related to animals administered substances known or suspected to be hazardous to humans.
ULAM Non-Approved Vendors
This is a subset of the Approved Vendor list. These are vendors which, for any of several reasons, the faculty veterinarians have not granted either “ULAM Approved Vendor” or “ULAM Conditionally Approved Vendor” status. Animals coming from these vendors must be quarantined upon arrival, and their receipt is coordinated by the RHST’s import coordinator. For large animal shipments, the import coordinator will work closely with the faculty veterinarians. Investigators have the option of purchasing animals from these vendors themselves and going through their departments to pay for them, or having the RHST’s import coordinator work with the ULAM Business Office to do this for them.
- Obtaining rodents from non-approved vendors: Requests for rats and mice from non-approved vendors should be directed to the ULAM Rodent Health Surveillance Team
- Obtaining USDA species from non-approved vendors: Requests for hamsters, gerbils, guinea pigs and rabbits from non-approved vendors should be directed to the veterinary faculty for evaluation of the animal source
Ultra-PAK (Bio-PAK Prefilter)
An air filtration/dessicator system attached to each rack, except in CC where there are 1-2 installed per pod. The Prefilter is a wire-rimmed filter that is removed, washed and replaced every two weeks. The Ultra-PAK system removes particulate matter from the air and maintains a constant specific level of humidity in the room.
A young animal that is hunched and scruffy, quiet, lethargic or otherwise appears sick.
Veterinary Technical Staff is unable to differentiate whether the condition is spontaneous or induced by research.
United States Department of Agriculture. The USDA's Animal and Plant Health Inspection Service oversees activities involving the use of vertebrate animals at government-registered research institutions. The USDA receives its authority through federal law (Code of Federal Regulations, Title 7 and 9). Veterinary Medical Officers enforcing the 7 and 9 CFRs inspect research organizations at least annually.
A term that refers to animals whose care is governed by the Animal Welfare Act. USDA-regulated Species include all live or dead warm-blooded animals used in research except birds, rats of the genus Rattus, and mice of the genus Mus bred for research. This also excludes "cold-blooded" animals such as fish, reptiles, and amphibians.
The number assigned to each individual order (e.g., F12345) and noted on both the preprinted cage card and the delivery schedule below the PI's name and account number.