Animals that have no microorganisms living in or on them and are raised within germ-free isolators in order to control their exposure to viral, bacterial, or parasitic agents.
Germ-Free Animals
GP 100
A multi-purpose detergent and degreaser used to clean large animal pens and cage wash room floors. Use with orange foamer tip or power washer.
Gravity or Prevac Cycle
The autoclave cycle used for solid or dry items ONLY (e.g., not for use with liquids).
Green or Clean Rooms
Animal rooms clean from any contaminants such as MPV, Pinworm, Orf, Q-Fever etc.
Grit
Sand or bits of crushed rock that chickens eat and store in their crop for proper digestion of food.
Harem
Alternative breeding strategy in which three to four adult females are co-housed with one adult male resulting in multiple pregnancies. All but one female must be removed from the cage. Breeding records documenting problem breeding can be submitted as scientific justification to house two adult females, one adult male, and two litters in the cage as described by the definition of trio breeding. Singly housed pregnant females or stud males should be labeled with a blue tab as described in the Identifying Single Housed Animals SOP.
Hazardous Chemical
A chemical for which there is evidence that acute or chronic health effects may occur in exposed employees. Examples include carcinogens, teratogens, and corrosives.
Hazardous Materials
Hazardous Materials are those materials that constitute a hazard to humans or the environment. The Policy on the Use of Hazardous Materials in Animal Activities applies to the specific hazardous materials listed below when used in conjunction with vertebrate animals:
- Biological agents requiring handling conditions above Biosafety Level 1 (BSL-1).
- Biological agents requiring animals to be housed in conditions above Animal Biosafety Level 1 (ABSL-1).
- Biological specimens (e.g., saliva, blood, and urine) collected from humans or non-human primates.
- Biological toxins (e.g., Botulinum toxin including cosmetic BOTOX).
- Activities involving non-exempt recombinant or synthetic nucleic acid molecules technology (rDNA techniques).
- HHS and USDA Select Agents and Toxins, as defined in Federal Regulations 7 CFR 331, 9 CFR 121, and 42 CFR 73. The current list is available at https://www.selectagents.gov/SelectAgentsandToxinsList.html.
- Activities involving any radiation producing equipment or materials including ionizing, non-ionizing, x-rays, and lasers.
- Chemicals designated by the National Institute of Occupational Safety and Health (NIOSH) as hazardous drugs, carcinogens, reproductive hazards, nanoparticles, or toxic chemicals, as well as materials that may have serious impact on the environment during release or disposal that are used in conjunction with animals.
Hazardous Waste Label
Used to label hazardous waste containers within an animal room. Records start date and hazards contained within the container.
Hazardous Waste Stickers
Stickers used on bins holding chemical waste, including sharps, that have been exposed to Animal Biosafety Level 2 chemicals.
HDS
Human-derived substance(s).
Health Report
A set of test results obtained from routine quarterly sentinel testing.
Health/Group Health Record
A record maintained by investigative personnel detailing the care and management (treatments, monitoring, etc.) of a health condition that is performed by the laboratory personnel under the direction of the ULAM veterinary staff.
A single record can be used for multiple animals (a group health record) if:
- All animals are being treated/monitored in the same way and for the same condition, and
- The animals are housed together in one cage and share a single clinical number.
- Components of a health/group health record include:
- Identification of the animal(s)
- Clinical observations/monitoring
- Treatment information
- Drug
- Dose
- Route
- Time/frequency given
- Date and initial all entries
Healthy Pup
A young animal that is bright, alert, responsive, hydrated, and otherwise does not appear sick.
Heat Lamps
Infrared bulb used as a heat source that can NOT be Teflon coated due to toxicity.
HEPA Filter
High-Efficiency Particulate Air (HEPA) filters remove 99.97% of all particles 0.3 μm in size.
Hypnosis
Artificially induced sleep induced by central nervous system (CNS) depression.
Identification
The process of uniquely marking an animal so it can be differentiated from other animals within a group.
Ignition Source
Some examples of ignition sources include fiber optic light sources, defibrillators, drills, burs, surgical lasers, electrosurgical equipment, and electrocautery equipment.
IM
Intramuscular.
Immersion
A method of delivering drugs via direct contact with the skin in a bath.
Immunologic Adjuvant
Agents that non-specifically increase immune responses to specific antigens that are weakly immunogenic.
Import Quarantine (IQ)
Standard ten-week quarantine procedures.
Inactive Case
Those involving animals that are no longer being treated and/or monitored. Cases become inactive when:
- A clinical condition is resolved by the veterinary staff.
- The animal is euthanized or un-enrolled from study.
- The animal is transferred to another laboratory or institution.
Inappetence
Loss or lack of appetite.
Individually Housed
Describes primates housed without tactile contact to another primate. Still has visual and olfactory contact with other primates.
Induration
Localized hardening of the soft tissue of the body.
Infectious / Chemical Agent Form
Form that describes the infectious or chemical hazard for each investigator, located in a binder within the containment housing or procedure room.
Infectious Agent (Biologic Agent)
A live organism (e.g. virus, bacteria, rickettsia, fungi, parasite) capable of causing disease in humans/animals, human/animal tissue (normal or diseased) including all human-derived substances.
Inquiry
Inquiry is an official period of time used to collect information associated with a report or allegation. It is also used to determine whether an allegation or incident warrants IACUC investigation.
Institutional Animal Care & Use Committee (IACUC)
Institutional Animal Care & Use Committee. The IACUC is ultimately responsible for approving, requiring modification of, or prohibiting the use of vertebrate animals in research, teaching, and/or testing activities at the University of Michigan. This includes supervision, coordination, training, guidance, and review of every project proposed to include the use of vertebrate animals to ensure that the project has appropriate scientific merit.
Intracranial
Administration of substances into the brain.
Intradermal (ID)
Administration of substances into the dermis.
Intranasal (IN)
Administration of substances into the nose.
Intrapalpebral
Within the palpebrum.
Intraperitoneal (IP)
Administration of substances into the abdominal cavity.
Intrathecal (IT)
Administration of substances into the subarachnoid space (in the spinal canal but not within the spinal cord).
Intratracheal (IT)
Administration of substances within the trachea.
Introduction
The initial observation and attempt to pair house two non-human primates.
Investigation
Investigation is the formal IACUC review of information gathered during the inquiry process. It includes the discussion and evaluation of the relevant facts to determine, for example, whether non-compliance occurred. During this process, the IACUC also quantifies the significance of the incident and identifies the appropriate corrective actions to be taken.
