Investigation is the formal IACUC review of information gathered during the inquiry process. It includes the discussion and evaluation of the relevant facts to determine, for example, whether non-compliance occurred. During this process, the IACUC also quantifies the significance of the incident and identifies the appropriate corrective actions to be taken.
Institutional Official. The IO bears ultimate responsibility for the University of Michigan's Animal Care & Use Program. The IO works closely with the Assistant Vice President for Research – Animal Compliance Oversight and Director of the Animal Care & Use Office; the Assistant Vice President for Research – Animal Resources and U-M Attending Veterinarian; and the Institutional Animal Care & Use Committee Chair to oversee all aspects of animal research at the University of Michigan.
In-Vivo Animal Core; a division of the Unit for Laboratory Animal Medicine that includes the Animal Diagnostic Laboratory.
Fish that are 30 to 89 dpf.
To give birth.
Infant rabbit still with their mother.
Lab Will Care Log
This form serves as the log sheet for research personnel to indicate care (feed, water, cage change) provided to the animals. These are typically placed on the inside of the animal room door.
A citric acid detergent used to pretreat large animal equipment.
A multi-purpose, neutral pH germicidal disinfectant and deodorant which is used to sanitize rooms. Use with light purple foamer tip.
- Dilution .125 oz Labsan 256CPQ per 32 oz. water when using a 32 oz. spray bottle.
Laminar Flow Hood (LFH)
An enclosure in which room air is drawn through a HEPA filter and the blown in a very smooth and vertical, laminar flow so as to prevent contamination of animals by airborne organisms.
Large Animal Species
Dog, Cat, Swine, Sheep, Primate.
0 to 29-day old fish.
Laminar Flow Hood.
The autoclave cycle to be used for autoclave loads that contain any amount of liquids. This cycle must be used for all supplies coming out of containment housing rooms.
The mouthpiece of a water source leading into the cage made of a stainless steel tube that allows the animal free access to water.
A loss of sensation in a restricted body area creating a local area of analgesia.
A local anesthetic is a drug that blocks sensation from a specific area of the body, such as lidocaine or bupivacaine.
Local Processor (LP)
Silver panel outside of rooms have the Edstrom system that displays information pertaining to the environmental conditions (e.g., humidity, light, temperature, etc.) in the room.
Long-Term Personnel are defined as individuals participating in a research or learning activity for more than 30 consecutive days (1 month) or more than 15 total days over a six-month period.
Rabbits greater than, or equal to, 2 years of age housed within ULAM facilities.
Loose Animal (Rodent)
Any mouse or rat that falls on the floor of the animal room or procedure room.
An instrument that displays the relative pressure of a room.
Major Recovery Surgery
A surgical intervention that penetrates a body cavity (i.e. cranial, thoracic, abdominal, synovial, pelvic, ocular or orbital, skeletal, joint or bone marrow), involves extensive tissue dissection or transection, or has the potential for producing a substantial impairment of a physical or physiological function.
Examples of major survival surgeries include:
- Tendon/ligament repair or injury
- All --otomies (e.g., lararotomy, tracheotomy) and --ectomies
- -Oscopies that involve incision (e.g., laparascopy)
- Implantation of central devices
- Eye surgery involving corneal incision
- Central cannulation (central approach)
- Musculoskeletal system repair, injury, or biopsy
- Extensive tissue dissection/transection (e.g., nerve or muscle cut-down)
Some surgeries may be classified as major or minor depending on various factors, and may be evaluated on a case-by-case basis.
- Factors that can influence the classification may include the duration of anesthesia, size and location of the incisions, amount of tissue dissection and characteristics of the animal to undergo surgery.
A change in the composition of the normally offered food or water. This can include addition or deletion of a nutrient in an animal diet and/or addition of a compound, medication or other substance to the food or drinking water provided to the animal.
Master Problem List
A list of an animal's health problems that serves as an index to its permanent medical record. It includes each problem, and the dates each was noted and resolved.
A diagnostic method to provide quantification of intestinal parasite eggs in feces, reported as eggs per gram (EPG).
Medical Surveillance Questionnaire
All personnel must be enrolled in the Animal Handler Medical Surveillance Program if they will perform the following tasks:
- Handles, restrains, collects specimens from, or administers substances to, live vertebrate animals.
- Does not conduct procedures on live animals, but handles animal waste, "unfixed" animal tissues, non-sanitized animal caging/enclosures, or body fluids.
- Observes animals or enters animal facility only. No direct contact with animals: inspector, maintenance personnel, etc.
Departments with personnel that meet the requirements of the program will be notified by the eRAM system to complete the Medical Surveillance Questionnaire.
Mouse Hepatitis Virus.
Cages maintained for animals in a Specific Pathogen Free (SPF) status.
Micro-isolation (MI) Technique
A method of housing and handling animals to maintain them free of disease-causing pathogens.
Micro-isolator (MI) Top
Micro-isolator (MI) top; used as a cover on rodent cages to prevent contamination within the cage.
Date that the food was formulated by the manufacturer.
Minor Recovery Surgery
A surgical intervention that does not expose a body cavity or that does not ordinarily have the potential to result in impairment of a vital physical or physiological function.
Examples of minor survival surgeries include:
- Cranial burr holes that do not expose dura or brain
- Subcutaneous implants
- Peripheral vessel cannulation (peripheral approach)
- Castration (scrotal or prescrotal approach)
- Oral surgery and tooth extractions not involving bone
- -Oscopies into natural openings that involve biopsy
- Small digit or tail amputation
- Surgical repair of superficial injury
Minors are defined as anyone under the age of 18.
Minute Mouse Virus.
A severely debilitated state that precedes imminent death.
Mobile shelving unit.