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Inquiry is an official period used to collect information associated with an allegation or report. The purpose of the inquiry is to decide if an allegation or report warrants an IACUC investigation. If a determination is made to proceed to an investigation, the ACC must notify all involved parties, including, when possible, the individual(s) who reported the allegation.

Institutional Animal Care & Use Committee (IACUC)

Institutional Animal Care & Use Committee. The IACUC is ultimately responsible for approving, requiring modification of, or prohibiting the use of vertebrate animals in research, teaching, and/or testing activities at the University of Michigan. This includes supervision, coordination, training, guidance, and review of every project proposed to include the use of vertebrate animals to ensure that the project has appropriate scientific merit. 

Institutional Official (IO)

Institutional Official (IO). The IO bears ultimate responsibility for the University of Michigan's Animal Care & Use Program. The IO works closely with the Assistant Vice President for Research – Animal Compliance Oversight and Director of the Animal Care & Use Office; the Assistant Vice President for Research – Animal Resources and U-M Attending Veterinarian; and the Institutional Animal Care & Use Committee Chair to oversee all aspects of animal research at the University of Michigan.


Administration of substances into the brain.

Intradermal (ID)

Administration of substances into the dermis.

Intranasal (IN)

Administration of substances into the nose.


Within the palpebrum.

Intraperitoneal (IP)

Administration of substances into the abdominal cavity.

Intrathecal (IT)

Administration of substances into the subarachnoid space (in the spinal canal but not within the spinal cord).

Intratracheal (IT)

Administration of substances within the trachea.


The initial observation and attempt to pair house two non-human primates.


Lead by the ACC during a convened meeting of at least a quorum of the IACUC; a formal development of a factual record and the examination of that record leading to a decision to determine, for example, whether noncompliance occurred. During the investigation, the IACUC also quantifies the significance of the incident and identifies the appropriate corrective actions to be taken.




In-Vivo Animal Core; a division of the Unit for Laboratory Animal Medicine that includes the Animal Diagnostic Laboratory.


Fish that are 30 to 89 dpf.


To give birth.


Infant rabbit still with their mother.

Lab Will Care Log

This form serves as the log sheet for research personnel to indicate care (feed, water, cage change) provided to the animals. These are typically placed on the inside of the animal room door.

Labsan 230C

A citric acid detergent used to pretreat large animal equipment.

Labsan 256CPQ

A multi-purpose, neutral pH germicidal disinfectant and deodorant which is used to sanitize rooms. Use with light purple foamer tip.

  • Dilution .125 oz Labsan 256CPQ per 32 oz. water when using a 32 oz. spray bottle.

Laminar Flow Hood (LFH)

An enclosure in which room air is drawn through a HEPA filter and the blown in a very smooth and vertical, laminar flow so as to prevent contamination of animals by airborne organisms.

Large Animal

Mammals ranging in size from cat to calf (including NHPs), typically housed in pens or runs.

Large Animal Veterinary Advisory Team (LAVA)

Body of veterinary faculty overseeing care and use of large animals in research.


0 to 29-day old fish.

Laying Hen

Hen bred specifically for egg laying.


Laminar Flow Hood.

Liquid Cycle

The autoclave cycle to be used for autoclave loads that contain any amount of liquids. This cycle must be used for all supplies coming out of containment housing rooms.


The mouthpiece of a water source leading into the cage made of a stainless steel tube that allows the animal free access to water.

Local Analgesia

A loss of sensation in a restricted body area creating a local area of analgesia.

Local Anesthetic

A local anesthetic is a drug that blocks sensation from a specific area of the body, such as lidocaine or bupivacaine.

Local Processor (LP)

Silver panel outside of rooms have the Edstrom system that displays information pertaining to the environmental conditions (e.g., humidity, light, temperature, etc.) in the room.

Long-Term Personnel

Long-Term Personnel are defined as individuals participating in a research or learning activity for more than 30 consecutive days (1 month) or more than 15 total days over a six-month period.

Long-Term Rabbits

Rabbits greater than, or equal to, 2 years of age housed within ULAM facilities.

Loose Animal (Rodent)

Any mouse or rat that falls on the floor of the animal room or procedure room.

Magnahelic Gauge

An instrument that displays the relative pressure of a room.

Major Recovery Surgery

A surgical intervention that penetrates a body cavity (i.e. cranial, thoracic, abdominal, synovial, pelvic, ocular or orbital, skeletal, joint or bone marrow), involves extensive tissue dissection or transection, or has the potential for producing a substantial impairment of a physical or physiological function.

Examples of major survival surgeries include:

  • Tendon/ligament repair or injury
  • Ovariohysterectomy
  • All --otomies (e.g., lararotomy, tracheotomy) and --ectomies
  • -Oscopies that involve incision (e.g., laparascopy)
  • Implantation of central devices
  • Amputation
  • Enucleation
  • Eye surgery involving corneal incision
  • Central cannulation (central approach)
  • Musculoskeletal system repair, injury, or biopsy
  • Extensive tissue dissection/transection (e.g., nerve or muscle cut-down)

Some surgeries may be classified as major or minor depending on various factors, and may be evaluated on a case-by-case basis.

  • Factors that can influence the classification may include the duration of anesthesia, size and location of the incisions, amount of tissue dissection and characteristics of the animal to undergo surgery.


A change in the composition of the normally offered food or water. This can include addition or deletion of a nutrient in an animal diet and/or addition of a compound, medication or other substance to the food or drinking water provided to the animal.

Master Problem List

A list of an animal's health problems that serves as an index to its permanent medical record. It includes each problem, and the dates each was noted and resolved.

McMaster Test

A diagnostic method to provide quantification of intestinal parasite eggs in feces, reported as eggs per gram (EPG).

Medical Surveillance Questionnaire

All personnel must be enrolled in the Animal Handler Medical Surveillance Program if they will perform the following tasks:

  1. Handles, restrains, collects specimens from, or administers substances to, live vertebrate animals.
  2. Does not conduct procedures on live animals, but handles animal waste, "unfixed" animal tissues, non-sanitized animal caging/enclosures, or body fluids.
  3. Observes animals or enters animal facility only. No direct contact with animals: inspector, maintenance personnel, etc.

Departments with personnel that meet the requirements of the program will be notified by the eRAM system to complete the Medical Surveillance Questionnaire.